| R50 | Fever of other and unknown origin |
| R50.2 | Drug induced fever |
| R50.8 | Other specified fever |
| R50.81 | Fever presenting with conditions classified elsewhere |
| R50.82 | Postprocedural fever |
| R50.83 | Postvaccination fever |
| R50.84 | Febrile nonhemolytic transfusion reaction |
| R50.9 | Fever, unspecified |
| R51 | Headache |
| R52 | Pain, unspecified |
| R53 | Malaise and fatigue |
| R53.0 | Neoplastic (malignant) related fatigue |
| R53.1 | Weakness |
| R53.2 | Functional quadriplegia |
| R53.8 | Other malaise and fatigue |
| R53.81 | Other malaise |
| R53.82 | Chronic fatigue, unspecified |
| R53.83 | Other fatigue |
| R54 | Age-related physical debility |
| R55 | Syncope and collapse |
| R56 | Convulsions, not elsewhere classified |
| R56.0 | Febrile convulsions |
| R56.00 | Simple febrile convulsions |
| R56.01 | Complex febrile convulsions |
| R56.1 | Post traumatic seizures |
| R56.9 | Unspecified convulsions |
| R57 | Shock, not elsewhere classified |
| R57.0 | Cardiogenic shock |
| R57.1 | Hypovolemic shock |
| R57.8 | Other shock |
| R57.9 | Shock, unspecified |
| R58 | Hemorrhage, not elsewhere classified |
| R59 | Enlarged lymph nodes |
| R59.0 | Localized enlarged lymph nodes |
| R59.1 | Generalized enlarged lymph nodes |
| R59.9 | Enlarged lymph nodes, unspecified |
| R60 | Edema, not elsewhere classified |
| R60.0 | Localized edema |
| R60.1 | Generalized edema |
| R60.9 | Edema, unspecified |
| R61 | Generalized hyperhidrosis |
| R62 | Lack of expected normal physiological development in childhood and adults |
| R62.0 | Delayed milestone in childhood |
| R62.5 | Other and unspecified lack of expected normal physiological development in childhood |
| R62.50 | Unspecified lack of expected normal physiological development in childhood |
| R62.51 | Failure to thrive (child) |
| R62.52 | Short stature (child) |
| R62.59 | Other lack of expected normal physiological development in childhood |
| R62.7 | Adult failure to thrive |
| R63 | Symptoms and signs concerning food and fluid intake |
| R63.0 | Anorexia |
| R63.1 | Polydipsia |
| R63.2 | Polyphagia |
| R63.3 | Feeding difficulties |
| R63.4 | Abnormal weight loss |
| R63.5 | Abnormal weight gain |
| R63.6 | Underweight |
| R63.8 | Other symptoms and signs concerning food and fluid intake |
| R64 | Cachexia |
| R65 | Symptoms and signs specifically associated with systemic inflammation and infection |
| R65.1 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin |
| R65.10 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction |
| R65.11 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction |
| R65.2 | Severe sepsis |
| R65.20 | Severe sepsis without septic shock |
| R65.21 | Severe sepsis with septic shock |
| R68 | Other general symptoms and signs |
| R68.0 | Hypothermia, not associated with low environmental temperature |
| R68.1 | Nonspecific symptoms peculiar to infancy |
| R68.11 | Excessive crying of infant (baby) |
| R68.12 | Fussy infant (baby) |
| R68.13 | Apparent life threatening event in infant (ALTE) |
| R68.19 | Other nonspecific symptoms peculiar to infancy |
| R68.2 | Dry mouth, unspecified |
| R68.3 | Clubbing of fingers |
| R68.8 | Other general symptoms and signs |
| R68.81 | Early satiety |
| R68.82 | Decreased libido |
| R68.83 | Chills (without fever) |
| R68.84 | Jaw pain |
| R68.89 | Other general symptoms and signs |
| R69 | Illness, unspecified |