| D80 | Immunodeficiency with predominantly antibody defects |
| D80.0 | Hereditary hypogammaglobulinemia |
| D80.1 | Nonfamilial hypogammaglobulinemia |
| D80.2 | Selective deficiency of immunoglobulin A [IgA] |
| D80.3 | Selective deficiency of immunoglobulin G [IgG] subclasses |
| D80.4 | Selective deficiency of immunoglobulin M [IgM] |
| D80.5 | Immunodeficiency with increased immunoglobulin M [IgM] |
| D80.6 | Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia |
| D80.7 | Transient hypogammaglobulinemia of infancy |
| D80.8 | Other immunodeficiencies with predominantly antibody defects |
| D80.9 | Immunodeficiency with predominantly antibody defects, unspecified |
| D81 | Combined immunodeficiencies |
| D81.0 | Severe combined immunodeficiency [SCID] with reticular dysgenesis |
| D81.1 | Severe combined immunodeficiency [SCID] with low T- and B-cell numbers |
| D81.2 | Severe combined immunodeficiency [SCID] with low or normal B-cell numbers |
| D81.3 | Adenosine deaminase [ADA] deficiency |
| D81.4 | Nezelof's syndrome |
| D81.5 | Purine nucleoside phosphorylase [PNP] deficiency |
| D81.6 | Major histocompatibility complex class I deficiency |
| D81.7 | Major histocompatibility complex class II deficiency |
| D81.8 | Other combined immunodeficiencies |
| D81.81 | Biotin-dependent carboxylase deficiency |
| D81.810 | Biotinidase deficiency |
| D81.818 | Other biotin-dependent carboxylase deficiency |
| D81.819 | Biotin-dependent carboxylase deficiency, unspecified |
| D81.89 | Other combined immunodeficiencies |
| D81.9 | Combined immunodeficiency, unspecified |
| D82 | Immunodeficiency associated with other major defects |
| D82.0 | Wiskott-Aldrich syndrome |
| D82.1 | Di George's syndrome |
| D82.2 | Immunodeficiency with short-limbed stature |
| D82.3 | Immunodeficiency following hereditary defective response to Epstein-Barr virus |
| D82.4 | Hyperimmunoglobulin E [IgE] syndrome |
| D82.8 | Immunodeficiency associated with other specified major defects |
| D82.9 | Immunodeficiency associated with major defect, unspecified |
| D83 | Common variable immunodeficiency |
| D83.0 | Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function |
| D83.1 | Common variable immunodeficiency with predominant immunoregulatory T-cell disorders |
| D83.2 | Common variable immunodeficiency with autoantibodies to B- or T-cells |
| D83.8 | Other common variable immunodeficiencies |
| D83.9 | Common variable immunodeficiency, unspecified |
| D84 | Other immunodeficiencies |
| D84.0 | Lymphocyte function antigen-1 [LFA-1] defect |
| D84.1 | Defects in the complement system |
| D84.8 | Other specified immunodeficiencies |
| D84.9 | Immunodeficiency, unspecified |
| D86 | Sarcoidosis |
| D86.0 | Sarcoidosis of lung |
| D86.1 | Sarcoidosis of lymph nodes |
| D86.2 | Sarcoidosis of lung with sarcoidosis of lymph nodes |
| D86.3 | Sarcoidosis of skin |
| D86.8 | Sarcoidosis of other sites |
| D86.81 | Sarcoid meningitis |
| D86.82 | Multiple cranial nerve palsies in sarcoidosis |
| D86.83 | Sarcoid iridocyclitis |
| D86.84 | Sarcoid pyelonephritis |
| D86.85 | Sarcoid myocarditis |
| D86.86 | Sarcoid arthropathy |
| D86.87 | Sarcoid myositis |
| D86.89 | Sarcoidosis of other sites |
| D86.9 | Sarcoidosis, unspecified |
| D89 | Other disorders involving the immune mechanism, not elsewhere classified |
| D89.0 | Polyclonal hypergammaglobulinemia |
| D89.1 | Cryoglobulinemia |
| D89.2 | Hypergammaglobulinemia, unspecified |
| D89.3 | Immune reconstitution syndrome |
| D89.8 | Other specified disorders involving the immune mechanism, not elsewhere classified |
| D89.81 | Graft-versus-host disease |
| D89.810 | Acute graft-versus-host disease |
| D89.811 | Chronic graft-versus-host disease |
| D89.812 | Acute on chronic graft-versus-host disease |
| D89.813 | Graft-versus-host disease, unspecified |
| D89.82 | Autoimmune lymphoproliferative syndrome [ALPS] |
| D89.89 | Other specified disorders involving the immune mechanism, not elsewhere classified |
| D89.9 | Disorder involving the immune mechanism, unspecified |